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EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.
1190002P15Rik; EIF-2B; eIF-2B GDP-GTP exchange factor subunit gamma; EIF2B3; Eif2bg; EIF2Bgamma; eukaryotic translation initiation factor 2B subunit gamma; eukaryotic translation initiation factor 2B, subunit 3; eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD); eukaryotic translation initiation factor 2B, subunit 3 gamma; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; translation initiation factor eIF-2B subunit gamma; Translation initiation factor eIF-2B subunit gamma-like protein
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